Ligand Efficiency Calculator

How to Use the Ligand Efficiency Calculator

1. Enter the IC₅₀ value in nM (nanomolar) in the "IC₅₀ (nM)" field.
2. Enter the number of heavy atoms in the ligand in the "Number of Heavy Atoms" field.
3. Click the "Calculate" button to compute the Ligand Efficiency.
4. The result will be displayed in the "Result" field.

Understanding Ligand Efficiency

Ligand efficiency (LE) is a measure of the efficiency of a ligand in binding to a target molecule, typically a protein or enzyme. It is calculated as the logarithm (base 10) of the IC₅₀ divided by the number of heavy atoms in the ligand. A higher LE value indicates a more efficient ligand.

Formula

LE = log₁₀(IC₅₀) / n

Where:

• LE is Ligand Efficiency
• IC₅₀ is the half maximal inhibitory concentration
• n is the number of heavy atoms in the ligand