Amlodipine Dissolution Heat Calculator

How to Use the Calculator

1. Enter the concentration of amlodipine in mg/mL.
2. Enter the volume of the solution in mL.
3. Enter the specific heat capacity of the solvent in J/g°C. The default value is 4.184 (for water).
4. Enter the temperature change during dissolution in °C.
5. Click the "Calculate" button to compute the dissolution heat and the mass of amlodipine.
6. Click the "Reset" button to clear all input fields and start over.

Working Principle

The dissolution heat (Q) is calculated using the formula Q = m × c × ΔT, where:

• m is the mass of amlodipine in grams, calculated as Concentration (mg/mL) × Volume (mL) × 0.001.
• c is the specific heat capacity of the solvent in J/g°C.
• ΔT is the temperature change during dissolution in °C.

Example

If you have a 5 mg/mL amlodipine solution with a volume of 100 mL, dissolved in water (specific heat capacity = 4.184 J/g°C), and the temperature changes by 10°C, the dissolution heat can be calculated as follows:

1. Mass of amlodipine = 5 mg/mL × 100 mL × 0.001 = 0.5 g
2. Dissolution heat = 0.5 g × 4.184 J/g°C × 10°C = 20.92 J